The IOI center encompasses four partners: AnyBody Technology A/S (ABT), CCBR A/S (CCBR) and Department of Mechanical and Manufacturing Engineering (M-Tech) and SMI. The center conducts research in advanced technology for management of knee osteoarthritis (KOA). The vision for the project is to develop an advanced workflow for optimal individualized, non-surgical management of knee osteoarthritis (KOA). The objectives are to design patient-specific interventions (braces, insoles and training regimes) and verify the effects of these interventions using patient-specific biomechanical simulation as well as functional assessments. The research group will develop a unique set of synergistic biomedical engineering and computational skills and tools.